Author

C. Saygin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

O. Reizes· 2 shared P. G. Rose· 2 shared R. Debernardo· 2 shared A. B. Nagaraj· 1 shared A. Chumakova· 1 shared A. DiFeo· 1 shared A. Jarrar· 1 shared A. Trestan· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

O. Reizes

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3 papers

Recent·Most cited

Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.

G. Parriott, E. Hegermiller, R. E. Morman, C. Frank, C. Saygin, W. Stock, E. T. Bartom, B. L. Kee

This study shows that E2a suppresses T-ALL by promoting T cell development and inter-thymocyte competition, preventing leukemogenesis.

bioRxiv · Apr 23, 2023 · PreprintCancer Biology

Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors

K. K. Crean-Tate, C. Braley, G. Dey, E. Esakov, C. Saygin, A. Trestan, D. J. Silver, S. M. Turaga, E. V. Connor, R. Debernardo, C. M. Michener, P. G. Rose, J. Lathia, O. Reizes

This study shows that pretreatment with LCK inhibitors makes cisplatin-resistant endometrioid ovarian tumors more sensitive to cisplatin, improving cell viability and tumor growth inhibition.

bioRxiv · Jun 18, 2020Cancer Biology

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

C. Saygin, A. Wiechert, V. S. Rao, R. Alluru, E. Connor, P. S. Thiagarajan, J. S. Hale, Y. Li, A. Chumakova, A. Jarrar, Y. Parker, D. J. Lindner, A. B. Nagaraj, J. J. Kim, A. DiFeo, , O. Reizes

This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.

bioRxiv · Jun 27, 2017Cancer Biology