Macrophages drive the earliest anti-tumoral response to BCG therapy by directly killing bladder cancer through TNF signaling
M. Martinez-Lopez, C. R. de Almeida, M. Fontes, R. V. Mendes, S. H. E. Kaufmann, R. Fior
This study identifies macrophages as key drivers of BCG therapy's anti-tumoral effect through direct TNF-mediated cancer cell killing, independent of adaptive immunity.
bioRxiv · Jan 5, 2024 · PreprintCancer Biology