Author

M. Fontes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Carlos Fonseca· 1 shared A. Filardy· 1 shared A. R. Todeschini· 1 shared A. V. Borderia· 1 shared A. Zippelius· 1 shared A. Zychlinsky Scharff· 1 shared C. de Souza Bastos· 1 shared C. R. de Almeida· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Carlos Fonseca

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrophages drive the earliest anti-tumoral response to BCG therapy by directly killing bladder cancer through TNF signaling

M. Martinez-Lopez, C. R. de Almeida, M. Fontes, R. V. Mendes, S. H. E. Kaufmann, R. Fior

This study identifies macrophages as key drivers of BCG therapy's anti-tumoral effect through direct TNF-mediated cancer cell killing, independent of adaptive immunity.

bioRxiv · Jan 5, 2024 · PreprintCancer Biology

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

N. Rodrigues Mantuano, M. A. Stanczak, I. de Araujo Oliveira, N. Kirchhammer, A. Filardy, G. Monaco, R. C. Santos, A. Carlos Fonseca, M. Fontes, C. de Souza Bastos, W. B. Dias, A. Zippelius, A. R. Todeschini, H. Laubli

This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.

bioRxiv · Nov 5, 2019Cancer Biology

Sex differences in IL-17 determine chronicity in male versus female urinary tract infection

A. Zychlinsky Scharff, M. Rousseau, L. Lacerda Mariano, T. Canton, M. Albert, M. Fontes, D. Duffy, M. A. Ingersoll

The paper investigates sex differences in urinary tract infection (UTI) severity, finding that male mice develop chronic infections due to impaired innate immunity, while females exhibit robust IL-17-driven responses that promote bacterial clearance.

bioRxiv · Oct 22, 2018Immunology

DISSEQT - DIStribution based modeling of SEQuence space Time dynamics

R. Henningsson, G. Moratorio, A. V. Borderia, M. Vignuzzi, M. Fontes

DISSEQT models sequence space dynamics of evolving microbial populations, revealing low-dimensional genetic spaces and predicting phenotype from genotype with high accuracy.

bioRxiv · May 21, 2018Evolutionary Biology