Author

R. Friedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:graph neural network· 1

Frequent Co-Authors

A. S. de Wijn· 1 shared G. Bourenkov· 1 shared G. Katona· 1 shared H. Rodilla· 1 shared I. Lundholm· 1 shared J. C. . Whitesell· 1 shared J. Roadnight Sheehan· 1 shared J. Stake· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiophysics

A. S. de Wijn

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3 papers

Recent·Most cited

Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice.

N. V. Balasenthilkumaran, J. C. . Whitesell, L. Pyle, R. Friedman, V. Kravets

The paper uses network analysis to show that in early insulitis, immune cells preferentially interact with β-cells in specific regions of pancreatic islets in NOD mice.

bioRxiv · May 6, 2024Bioengineering

Beyond IC50 - A computational dynamic model of drug resistance in enzyme inhibition treatment.

J. Roadnight Sheehan, A. S. de Wijn, T. S. Freire, R. Friedman

The paper develops a computational model to study drug resistance in Abl1 inhibitors for CML, finding that inhibitory reduction prowess better predicts resistance than traditional metrics.

bioRxiv · Mar 21, 2024 · PreprintBiophysics

A distributed lattice of aligned atoms exists in a protein structure: A hierarchical clustering study of displacement parameters in bovine trypsin

V. Ahlberg Gagner, I. Lundholm, M.-J. Garcia-Bonete, H. Rodilla, R. Friedman, V. Zhaunerchyk, G. Bourenkov, T. Schneider, J. Stake, G. Katona

This study examines how 0.5 THz irradiation affects atomic displacement parameters in bovine trypsin using hierarchical clustering to identify patterns in ADP similarities.

bioRxiv · Mar 13, 2019Biophysics