Author

L. Pyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

V. Kravets· 2 shared A. Hilkin· 1 shared A. M. Davis· 1 shared D. J. Hodson· 1 shared J. C. . Whitesell· 1 shared J. M. Dwulet· 1 shared J. Thurston· 1 shared K. Nadeau· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

V. Kravets

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice.

N. V. Balasenthilkumaran, J. C. . Whitesell, L. Pyle, R. Friedman, V. Kravets

The paper uses network analysis to show that in early insulitis, immune cells preferentially interact with β-cells in specific regions of pancreatic islets in NOD mice.

bioRxiv · May 6, 2024Bioengineering

Functional architecture of the pancreatic islets: First responder cells drive the first-phase response

V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger

The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.

bioRxiv · Dec 22, 2020Biophysics

Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Puberty: The Health Influences of Puberty Study

N. Nokoff, J. Thurston, A. Hilkin, L. Pyle, P. E. Zeitler, K. Nadeau, N. Santoro, M. Kelsey

This study examines sex differences in how obesity affects reproductive hormones and glucose metabolism in pubertal youth, finding differential impacts on hormone levels and insulin sensitivity between boys and girls.

bioRxiv · Dec 17, 2018 · PreprintPhysiology