Author

V. Kravets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

R. K. Benninger· 5 shared J. M. Dwulet· 4 shared W. E. Schleicher· 3 shared J. G. Miranda· 2 shared L. Pyle· 2 shared N. L. Farnsworth· 2 shared R. Piscopio· 2 shared A. Heintz· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersBiophysics

R. K. Benninger

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Author profile →

7 papers

Recent·Most cited

Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice.

N. V. Balasenthilkumaran, J. C. . Whitesell, L. Pyle, R. Friedman, V. Kravets

The paper uses network analysis to show that in early insulitis, immune cells preferentially interact with β-cells in specific regions of pancreatic islets in NOD mice.

bioRxiv · May 6, 2024Bioengineering

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

K. V. Nguyen Ngoc, S. Sai, Y. Jun, R. H. F. Bender, V. Kravets, H. Zhu, C. J. Hatch, M. Schlichting, R. Gaetani, M. Mallick, S. J. Hachey, K. Christman, S. C. George, C. C. Hughes, M. Sander

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

bioRxiv · Oct 28, 2022 · PreprintCell Biology

Beta-cell Metabolic Activity Rather than Gap Junction Structure Dictates Subpopulations in theIslet Functional Network

J. K. Briggs, V. Kravets, J. M. Dwulet, D. J. Albers, R. K. Benninger

The paper shows that metabolic activity, not gap junction structure, determines beta-cell subpopulations in the islet functional network.

bioRxiv · Feb 6, 2022Biophysics

Functional architecture of the pancreatic islets: First responder cells drive the first-phase response

V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger

The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.

bioRxiv · Dec 22, 2020Biophysics

RESTORING CONNEXIN-36 FUNCTION IN DIABETOGENIC ENVIRONMENTS PRECLUDES MOUSE AND HUMAN ISLET DYSFUNCTION

J. R. St Clair, M. J. Westacott, J. G. Miranda, N. L. Farnsworth, V. Kravets, W. E. Schleicher, J. M. Dwulet, C. H. Levitt, A. Heintz, N. W. F. Ludin, R. K. Benninger

This study shows that restoring Cx36 gap junction function in diabetic conditions improves islet function in both mice and humans.

bioRxiv · Nov 3, 2020Biophysics

Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice

M. E. C. do Amaral, V. Kravets, J. M. Dwulet, N. L. Farnsworth, R. Piscopio, W. E. Schleicher, J. G. Miranda, R. K. Benninger

This study shows caloric restriction improves β-cell coupling, calcium oscillations, and insulin secretion in prediabetic mice by restoring Cx36 gap junction function.

bioRxiv · Mar 3, 2020Physiology

Optogenetic Stimulation of Pancreatic Function via Vagal Cholinergic Axons

A. K. Fontaine, D. G. Ramirez, S. F. Littich, R. Piscopio, V. Kravets, J. H. Caldwell, R. F. Weir, R. K. Benninger

This study uses optogenetics to stimulate vagal cholinergic axons and shows increased insulin secretion and reduced glucose levels in mice.

bioRxiv · Dec 21, 2019Bioengineering