T. Schneider

Longitudinal Micro-Computed Tomography Detects Onset and Progression of Pulmonary Fibrosis in Conditional Nedd4-2 Deficient Mice

This study uses longitudinal micro-CT to detect and quantify the onset and progression of IPF-like lung disease in Nedd4-2-/- mice.

A new antibiotic from an uncultured bacterium binds to an immutable target

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

This study identifies perinuclear stress responses from nuclear envelope deterioration as contributors to LMNA cardiomyopathy using a mouse model and translatome profiling.

An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis

This study identifies an NlpC/P60 peptidase in Chlamydia trachomatis that recycles peptidoglycan to support cell division, energy recovery, and immune evasion.

Comparative phylogenomic analysis reveals evolutionary genomic changes and novel toxin families in endophytic Liberibacter pathogens

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

Bacterial galactosemia is caused by cytoplasmic interference of an essential cell wall biosynthesis glycosyltransferase

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

Unification of the M/ORF3-related proteins points to a diversified role for ion conductance in pathogenesis of coronaviruses and other nidoviruses

This study unifies M/ORF3-related proteins across coronaviruses and other nidoviruses, revealing their conserved role in ion conductance and virion assembly, while showing differential evolutionary pressures between M and ORF3 proteins.

"Select and retrieve via direct upsampling" network (SARDU-Net): a data-driven, model-free, deep learning approach for quantitative MRI protocol design

SARDU-Net is a deep learning framework for designing quantitative MRI protocols by selecting informative measurements from pilot scans, achieving high information content and reproducibility.

Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis Mechanisms of SARS-Related Coronaviruses

This study identifies novel Ig domain proteins in SARS-related coronaviruses, highlighting their rapid evolution and potential role in pathogenesis.

Faster 3D saturation-recovery based myocardial T1 mapping using a reduced number of saturation points and denoising

This paper accelerates 3D SASHA myocardial T1 mapping by reducing saturation points and using denoising, maintaining accuracy and precision.

A distributed lattice of aligned atoms exists in a protein structure: A hierarchical clustering study of displacement parameters in bovine trypsin

This study examines how 0.5 THz irradiation affects atomic displacement parameters in bovine trypsin using hierarchical clustering to identify patterns in ADP similarities.

The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity

This study shows that pentaglycine crosslinks in Staphylococcus aureus peptidoglycan are essential for cell integrity, as their absence leads to cell lysis and requires high osmolarity for survival.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.