Focused ultrasound stimulates ER localized mechanosensitive PANNEXIN-1 to mediate intracellular calcium release in invasive cancer cells
N. S. Lee, C. W. Yoon, Q. Wang, S. Moon, K. M. Koo, H. J. Jung, R. Chen, L. Jiang, G. Lu, A. Fernandez, R. H. Chow, A. C. Weitz, P. M. S. M. Salvaterra, F. Pinaud, K. K. Shung
This study shows focused ultrasound activates ER-localized PANX1 in invasive cancer cells, triggering calcium release and cytokine release, suggesting a new adjuvant therapy for cancer immunotherapy.
bioRxiv · Apr 3, 2020Cell Biology