Internal Translation of p53 Oncoproteins During Integrated Stress Response Confers Survival Advantage on Cancer Cells
M. J. Lopez-Iniesta, R. Lacerda, A. C. Ramalho, S. N. Parkar, A. Marques-Ramos, B. Pereira, L. Miyawaki, J. Fujita, R. Hrstka, L. Romao, M. M. Candeias
This study identifies the integrated stress response (ISR) as a trigger for p53 oncoprotein variants, showing their role in cancer cell survival and proposing a therapeutic strategy.
bioRxiv · Mar 3, 2023 · PreprintCancer Biology