SMAD4 governs a feedforward regulation of the TGF-beta effects in CD8 T cells that contributes to preventing chronic intestinal inflammation
R. Igalouzene, H. Hernandez-Vargas, N. Benech, D. Bauche, C. Barrachina, E. Dubois, J. C. Marie, S. M. SOUDJA
This study shows SMAD4 in CD8 T cells prevents chronic intestinal inflammation through a TGF-beta-independent feedforward mechanism by repressing TGF-beta imprinting and promoting IL-7 response and integrin expression.
bioRxiv · Feb 19, 2021 · PreprintImmunology