Memory CD8+ T cells mediate early pathogen-specific protection through localized delivery of chemokines and IFNγ to clusters of inflammatory monocytes
M. Boutet, Z. Benet, E. Guillen, C. Koch, S. M. SOUDJA, F. Delahaye, D. Fooksman, G. Lauvau
This study shows memory CD8+ T cells use cognate antigen to rapidly produce chemokines and IFNγ in splenic monocyte clusters, providing early pathogen protection before clonal expansion.
bioRxiv · Mar 1, 2021Immunology