Author

H. Hernandez-Vargas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2

Frequent Co-Authors

G. Ichim· 2 shared J. C. Marie· 2 shared K. Berthenet· 2 shared A. Bhadada· 1 shared A. Diederichs· 1 shared A. H. Abid· 1 shared A. Halaburkova· 1 shared A. Hennino· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

G. Ichim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Capture of circulating metastatic cancer cell clusters from a lung cancer patient can reveal a unique genomic profile and potential anti-metastatic molecular targets: A proof of concept study.

K. Kouhmareh, E. Martin, D. Finlay, A. Bhadada, H. Hernandez-Vargas, F. Downey, J. K. Allen, P. Teriete

This study captures metastatic cancer cell clusters from lung cancer patients and identifies their unique genomic profiles and potential anti-metastatic targets.

bioRxiv · Sep 19, 2023Cancer Biology

Single molecule DNA methylation and hydroxymethylation reveal unique epigenetic identity profiles of T helper cells

C. Goldsmith, O. Fesneau, V. Thevin, M. I. Matias, J. Perrault, A. H. Abid, N. Taylor, V. Dardalhon, J. C. Marie, H. Hernandez-Vargas

The paper develops a method to profile DNA methylation and hydroxymethylation in T helper cells, revealing their role in cell identity and potential for studying autoimmune disease mechanisms.

bioRxiv · Feb 3, 2023 · PreprintImmunology

Gene signature of circulating platelet-bound neutrophils is associated with poor prognosis in cancer patients

P. Lecot, M. Ardin, S. Dussurgey, V. Alcazer, L. Moudombi, M. Hubert, A. Swalduz, H. Hernandez-Vargas, A. Viari, C. Caux, M.-C. Michallet

The paper identifies a gene signature in neutrophil-platelet aggregates (NPAs) associated with poor prognosis in cancer patients.

bioRxiv · Aug 26, 2021Immunology

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

D. Fanfone, Z. C. Wu, J. Mammi, K. Berthenet, D. Neves, K. Weber, A. Halaburkova, F. Virard, F. Bunel, H. Hernandez-Vargas, S. W. Tait, A. Hennino, G. Ichim

This study shows that confined migration in breast cancer cells increases metastatic potential by promoting resistance to anoikis and enhancing invasiveness.

bioRxiv · Aug 17, 2021Cancer Biology

SMAD4 governs a feedforward regulation of the TGF-beta effects in CD8 T cells that contributes to preventing chronic intestinal inflammation

R. Igalouzene, H. Hernandez-Vargas, N. Benech, D. Bauche, C. Barrachina, E. Dubois, J. C. Marie, S. M. SOUDJA

This study shows SMAD4 in CD8 T cells prevents chronic intestinal inflammation through a TGF-beta-independent feedforward mechanism by repressing TGF-beta imprinting and promoting IL-7 response and integrin expression.

bioRxiv · Feb 19, 2021 · PreprintImmunology

Failed apoptosis enhances melanoma cancer cells aggressiveness

K. Berthenet, C. Castillo Ferrer, N. Popgeorgiev, H. Hernandez-Vargas, G. Ichim

The paper shows that failed apoptosis in melanoma cells leads to increased aggressiveness through transcriptomic changes and JNK pathway activation, observed in vitro and in vivo.

bioRxiv · Sep 5, 2019Cancer Biology

Interplay between the epigenetic enzyme lysine (K)-specific demethylase 2B and Epstein-Barr virus infection.

R. C. Vargas-Ayala, A. Jay, H. Hernandez-Vargas, A. Diederichs, A. Robitaille, C. Sirand, M. G. Ceraolo, M. Romero, M. P. Cros, C. Cuenin, G. Durand, F. Le Calvez-Kelm, L. Mundo, M. A. Maroui, L. Leoncini, , R. Accardi

This study shows EBV infection down-regulates KDM2B levels through epigenetic mechanisms, affecting both viral and host gene expression in B-cells.

bioRxiv · Jul 11, 2018Microbiology