Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway
R. Isotani, M. Igarashi, M. Miura, K. Naruse, S. Kuranami, M. Katoh, S. Nomura, T. Yamauchi
This study shows nicotine increases intestinal stem cell stemness and tumorigenicity through Hippo-YAP/TAZ and Notch pathways, and suggests DBZ as a potential therapeutic.
bioRxiv · Jan 2, 2024Cell Biology