M. Miura

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

This study shows nicotine increases intestinal stem cell stemness and tumorigenicity through Hippo-YAP/TAZ and Notch pathways, and suggests DBZ as a potential therapeutic.

Epidermal tyrosine catabolism is critical for metabolic homeostasis and survival against high-protein diets in Drosophila

The paper shows that Drosophila epidermis upregulates tyrosine catabolism via the AMPK-FoxO axis to adapt to high-protein diets, ensuring metabolic homeostasis and survival.

Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila

This study shows that methionine restriction during early adulthood extends lifespan in Drosophila by reducing oxidatively-damaged methionine through MsrA induction.

Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan

This study shows that specific bacterial peptidoglycans from Acetobacter persici shorten Drosophila lifespan and increase intestinal stem cell proliferation via gut receptors, while also enhancing stress resistance.

Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences

The paper identifies and characterizes DNA cytosine 5-methyltransferases with short recognition sequences that do not overlap with CG dinucleotides, enabling fine epigenetic mapping.

Fetal imidacloprid causes ASD-like impairment of biological motion perception in neonatal chicks

This study shows that fetal exposure to imidacloprid impairs biological motion perception in neonatal chicks, similar to effects seen with valproic acid and nAChR blockade.

Time-course of host cell transcription during the HTLV-1 transcriptional burst

This study examines how HTLV-1 transcriptional bursts affect host transcription over time in infected T-cells, finding transient activation of pathways like NF-κB and clone-specific differences in cell cycle regulation.

Preservation of collagen in the soft tissues of frozen mammoths

This study examines collagen preservation in frozen mammoth tissues, showing that collagen remains intact after 40,000 years in permafrost.

Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling

This study quantifies HTLV-1 reactivation kinetics using single-molecule RNA FISH and stochastic modeling, revealing rapid sense-strand transcription bursts and stable antisense transcription.

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

This study shows HTLV-1 disrupts host chromatin structure and causes abnormal transcription patterns in cis.