T. Yamauchi

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

This study shows nicotine increases intestinal stem cell stemness and tumorigenicity through Hippo-YAP/TAZ and Notch pathways, and suggests DBZ as a potential therapeutic.

Massive occurrence of benthic plastic debris at the abyssal seafloor beneath the Kuroshio Extension, the North West Pacific

The paper quantifies plastic debris on the abyssal seafloor beneath the Kuroshio Extension, finding high densities of single-use plastics, indicating the Northwest Pacific deep-sea basin is a major plastic reservoir.

CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1+ CD8+ T cells in mice

This study shows that CD40 and CD80/86 signaling in cDC1s enhances neoantigen vaccine efficacy and generates CX3CR1+ CD8+ T cells in mice.

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.

Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors

This paper evaluates HSET inhibitors in fission yeast to identify selective kinesin-14 inhibitors and assess their off-target effects.

Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in S. pombe

This study shows how two Kinesin-14 proteins in fission yeast generate inward forces against Kinesin-5 by localizing to different structures, maintaining spindle bipolarity.