R. J. Brownlie

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

Coordination of asparagine uptake and asparagine synthetase expression is required for T cell activation

The paper shows that coordinated asparagine uptake and asparagine synthetase expression is necessary for optimal CD8+ T cell activation and effector responses.