Author

R. J. Salmond

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

H. C. Hope· 2 shared R. J. Brownlie· 2 shared A. R. Teagle· 1 shared D. Wright· 1 shared G. P. Cook· 1 shared G. Pickersgill· 1 shared L. Steele· 1 shared N. Logan· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

H. C. Hope

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

A. R. Teagle, P. Castro-Sanchez, R. J. Brownlie, N. Logan, S. S. Kapoor, D. Wright, R. J. Salmond, R. Zamoyska

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

bioRxiv · Jun 24, 2023Immunology

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

H. C. Hope, G. Pickersgill, P. Ginefra, N. Vannini, G. P. Cook, R. J. Salmond

This study shows TGFβ suppresses Myc-driven metabolic changes in CD8+ T cells during activation by blocking amino acid uptake and glycolysis, while sparing mitochondrial respiration and mTOR activation.

bioRxiv · Mar 30, 2022Immunology

Coordination of asparagine uptake and asparagine synthetase expression is required for T cell activation

H. C. Hope, R. J. Brownlie, L. Steele, R. J. Salmond

The paper shows that coordinated asparagine uptake and asparagine synthetase expression is necessary for optimal CD8+ T cell activation and effector responses.

bioRxiv · Feb 28, 2020Immunology