R. Zamoyska

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

This study shows that mutations in the lncRNA RMRP impair pre-rRNA processing and T cell activation, linking CHH to a ribosomopathy.

This study shows that deleting PTPN22 in human T cells enhances their cytokine production and anti-tumor activity, suggesting improved function in the tumor microenvironment.

The paper identifies miR-7 as a modulator of T cell activation by showing its enrichment in HMW-RISC and its role in suppressing IL-2 signaling and metabolic processes.

The paper uses DNA-qPAINT to study Csk nano-clusters in T-cells, finding they regulate signaling by re-recruiting after stimulation and interacting with PTPN22.

The paper shows that differential nanoscale organisation of LFA-1 in T-cells modulates migration speed by linking actin flow and signaling.