Author

R. J. Hogan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:multiome· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

R. A. Tripp· 2 shared A. F. Lingappa· 1 shared A. Macieik· 1 shared A. Mueller-Schiffmann· 1 shared A. R. Moreira· 1 shared B. Onisko· 1 shared C. Nichols· 1 shared C. Zurla· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

R. A. Tripp

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro

J. Murray, R. J. Hogan, D. E. Martin, K. Blahunka, F. Sancillo, R. Balyan, M. Lovern, R. Still, R. A. Tripp

This study shows probenecid inhibits SARS-CoV-2 replication in mammalian cells and a hamster model, with achievable plasma concentrations supporting its potential clinical use.

bioRxiv · May 21, 2021Microbiology

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

M. Michon, A. Mueller-Schiffmann, A. F. Lingappa, S. F. Yu, L. Du, F. Deiter, S. Mallesh, J. Crabtree, U. F. Lingappa, A. Macieik, L. Mueller, P. N. Ostermann, M. Andree, O. Adams, H. Schaal, , K

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

bioRxiv · Jan 17, 2021Biochemistry

Treating Influenza and SARS-CoV-2 via mRNA-encoded Cas13a

E. L. Blanchard, D. Vanover, S. S. Bawage, P. M. Tiwari, L. Rotolo, J. Beyersdorf, H. E. Peck, N. C. Bruno, R. Hincapie, M. G. Finn, F. Michel, E. R. Lafontaine, R. J. Hogan, C. Zurla, P. J. Santangelo

This study uses mRNA-encoded Cas13a to target and reduce influenza and SARS-CoV-2 RNA in vitro and in a mouse model, showing potential for therapeutic applications.

bioRxiv · Apr 24, 2020 · PreprintBioengineering