Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture
L. Spoerri, C. A. Tonnessen-Murray, G. Gunasingh, D. S. Hill, K. A. Beaumont, R. J. Jurek, J. Chauhan, G. C. Vanwalleghem, M. E. Fane, S. M. Daignault-Mill, N. Matigian, G. M. Boyle, E. K. Scott, A. G. Smith, S. J. Stehbens, , N. K. Haass
This paper shows that melanoma phenotypic heterogeneity is controlled by cell-ECM crosstalk, altering tumor microarchitecture and mechanotransduction.
bioRxiv · Jun 9, 2020 · PreprintCancer Biology