Author

R. Jaksik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. Kimmel· 4 shared A. Gutierrez· 1 shared A. J. Cortez· 1 shared A. K. Fielding· 1 shared A. Krzywon· 1 shared A. Lambert· 1 shared A. Toma-Jonik· 1 shared A. Turna· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

M. Kimmel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

S. Rahman, G. Bloye, N. Farah, J. Demeulemeester, J. R. Costa, D. O'Connor, R. Pocock, A. Turna, L. Wang, S. Lee, A. K. Fielding, J. Roels, R. Jaksik, M. Dawidowska, P. V. Vlierberghe, , M. R. Mansour

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

bioRxiv · Feb 6, 2024Cancer Biology

Evolutionary analysis of genomes of SARS-CoV-2-related bat viruses suggests old roots, constant effective population size, and possible increase of fitness

M. K. Kurpas, R. Jaksik, M. Kimmel

The paper analyzes SARS-CoV-2-related bat viruses to estimate their evolutionary history, finding old roots, constant population size, and possible fitness increase.

bioRxiv · Feb 28, 2022 · PreprintEvolutionary Biology

Heat Shock Factor 1 (HSF1) as a new tethering factor for ESR1 supporting its action in breast cancer.

N. Vydra, P. Janus, P. Kus, T. Stokowy, K. Mrowiec, A. Toma-Jonik, A. Krzywon, A. J. Cortez, B. Wojtas, B. Gielniewski, R. Jaksik, M. Kimmel, W. Widlak

This study shows HSF1 enhances ESR1's genomic action in breast cancer, increases transcriptome diversity, and together they predict poor prognosis in ER-negative cancers.

bioRxiv · May 6, 2021Cancer Biology

Predicting Minimal Residual Disease in Acute Myeloid Leukemia through Stochastic Modeling of Clonality

K. N. Dinh, R. Jaksik, S. Corey, M. Kimmel

This paper develops a stochastic model to predict relapse in AML by analyzing MRD dynamics in a cohort of patients using whole genome sequencing data.

bioRxiv · Oct 2, 2019Cancer Biology

Statistical inference for the evolutionary history of cancer genomes

K. N. Đinh, R. Jaksik, M. Kimmel, A. Lambert, S. Tavare

This paper compares SFS derived from birth-death processes and coalescent models in cancer evolution, showing they can be made comparable and presents a selective sweep model for tumor history analysis.

bioRxiv · Aug 1, 2019Cancer Biology