B. Gielniewski

Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal

The paper identifies molecular differences in the hippocampus between AUD-prone and AUD-resistant mice during alcohol withdrawal.

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells

This study shows HDAC inhibitors reduce H3.3K27M protein levels in glioma cells, with H2A.Z facilitating this effect, suggesting a potential therapeutic strategy for DIPG.

Comprehensive analysis of the transcription factor REST regulatory networks in IDH-mutant and IDH-wild type glioma

This study identifies differences in REST regulatory networks between IDH-mutant and IDH-wild type gliomas, highlighting distinct gene expression control mechanisms.

Heat Shock Factor 1 (HSF1) as a new tethering factor for ESR1 supporting its action in breast cancer.

This study shows HSF1 enhances ESR1's genomic action in breast cancer, increases transcriptome diversity, and together they predict poor prognosis in ER-negative cancers.

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas

The paper maps chromatin accessibility and regulatory elements in human gliomas to identify new epigenetic mechanisms driving cancer progression.