Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
S. Rahman, G. Bloye, N. Farah, J. Demeulemeester, J. R. Costa, D. O'Connor, R. Pocock, A. Turna, L. Wang, S. Lee, A. K. Fielding, J. Roels, R. Jaksik, M. Dawidowska, P. V. Vlierberghe, , M. R. Mansour
The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.
bioRxiv · Feb 6, 2024Cancer Biology
A. L. Bruzos, M. Santamarina, D. Garcia Souto, S. Diaz, S. Rocha, J. Zamora, Y. Lee, A. Feas, M. Quail, I. Otero, A. Valtierra, J. Temes, J. Castro, A. Villanueva, D. Costas, , J. Tubio
This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.
bioRxiv · Aug 6, 2022 · PreprintEvolutionary Biology
E. G. Alvarez, J. Demeulemeester, C. Jolly, D. Garcia-Souto, P. Otero, A. Pequeno, J. Zamora, M. Tojo, J. Temes, A. Baez-Ortega, B. Rodriguez-Martin, Y. Li, A. Oitaben, A. L. Bruzos, M. Martinez-Fernandez, , J. Tubio
The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.
bioRxiv · Apr 19, 2021Cancer Biology
S. C. Dentro, I. Leshchiner, K. Haase, M. Tarabichi, J. Wintersinger, A. G. Deshwar, K. Yu, Y. Rubanova, G. Macintyre, J. Demeulemeester, I. Vazquez-Garcia, K. Kleinheinz, D. G. Livitz, S. Malikic, N. Donmez, , Q. D. Morris
This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.
Cell · Apr 1, 2021Peer-reviewedCancer Biology
J. Demeulemeester, S. C. Dentro, M. Gerstung, P. Van Loo
The paper identifies biallelic mutations in cancer genomes and highlights their implications for mutation hotspots and variant calling.
bioRxiv · Mar 29, 2021Cancer Biology
O. Marin-Bejar, A. Rogiers, M. Dewaele, J. Femel, P. Karras, J. Pozniak, G. Bervoets, N. Van Raemdonck, D. Pedri, T. Swings, J. Demeulemeester, S. Vander Borght, F. Bosisio, J. J. van den Oord, I. Vanden Bempt, , J.-C. Marine
This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.
bioRxiv · Dec 15, 2020 · PreprintCancer Biology
M. Gerstung, C. Jolly, I. Leshchiner, S. C. Dentro, S. Gonzalez Rosado, D. Rosebrock, T. J. Mitchell, Y. Rubanova, P. Anur, K. Yu, M. Tarabichi, A. Deshwar, J. Wintersinger, K. Kleinheinz, I. Vazquez-Garcia, , Spellman
This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.
bioRxiv · Sep 12, 2018Cancer Biology