R. Julian

A two-trick pony: lysosomal protease cathepsin B possesses surprising ligase activity

This study identifies cathepsin B as a protease with unexpected ligase activity, showing it can both cleave and join peptides through a two-step mechanism.

Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

This paper shows that isomerization of long-lived proteins in Alzheimer’s disease prevents lysosomal digestion, leading to lysosomal failure and linking AD to lysosomal storage disorders.

Structural and Functional Consequences of Age-Related Isomerization in α Crystallins

This study investigates how isomerization of amino acids in α- and β-crystallins affects protein assembly and function, showing significant disruptions in oligomerization and phosphorylation.