Targeting Scavenger Receptor Type B1 In Cholesterol-Addicted Lymphomas Abolishes Glutathione Peroxidase 4 and Results in Ferroptosis
J. S. Rink, A. Lin, K. M. McMahon, A. E. Calvert, S. Yang, T. Taxter, J. Moreira, A. Chadburn, A. Behdad, R. Karmali, C. S. Thaxton, L. I. Gordon
This study shows that targeting SCARB1 with HDL NPs in cholesterol-dependent lymphoma cells reduces GPX4, leading to ferroptosis and cell death.
bioRxiv · Jun 16, 2020 · PreprintCancer Biology