Author

K. M. McMahon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. S. Thaxton· 4 shared A. E. Murmann· 2 shared C. Law· 2 shared M. Patel· 2 shared A. Behdad· 1 shared A. Chadburn· 1 shared A. E. Calvert· 1 shared A. Haluck-Kangas· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

C. S. Thaxton

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4 papers

Recent·Most cited

Targeting Scavenger Receptor Type B-1 (SR-B1) and Cholesterol Inhibits Entry of SARS-CoV-2 Pseudovirus in Cell Culture

S. E. Henrich, K. M. McMahon, N. Palacio, P. Bhalla, P. Penaloza-MacMaster, C. S. Thaxton

This study shows that targeting SR-B1 with cholesterol-poor HDL nanoparticles inhibits SARS-CoV-2 pseudovirus entry in human cells.

bioRxiv · Dec 14, 2020 · PreprintMicrobiology

Targeting Scavenger Receptor Type B1 In Cholesterol-Addicted Lymphomas Abolishes Glutathione Peroxidase 4 and Results in Ferroptosis

J. S. Rink, A. Lin, K. M. McMahon, A. E. Calvert, S. Yang, T. Taxter, J. Moreira, A. Chadburn, A. Behdad, R. Karmali, C. S. Thaxton, L. I. Gordon

This study shows that targeting SCARB1 with HDL NPs in cholesterol-dependent lymphoma cells reduces GPX4, leading to ferroptosis and cell death.

bioRxiv · Jun 16, 2020 · PreprintCancer Biology

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

A. E. Murmann, Q. Q. Gao, W. Putzbach, M. Patel, E. T. Bartom, C. Law, B. Bridgeman, S. Chen, K. M. McMahon, C. S. Thaxton, M. E. Peter

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

bioRxiv · Jan 12, 2018Cancer Biology

Induction of DISE in ovarian cancer cells in vivo

A. E. Murmann, K. M. McMahon, A. Haluck-Kangas, N. Ravindran, M. Patel, C. Law, S. Brockway, J.-J. Wei, C. S. Thaxton, M. Peter

This study shows that DISE can be induced in ovarian cancer cells in vivo using siRNA-TLPs, leading to tumor growth reduction.

bioRxiv · Sep 10, 2017Cancer Biology