A reference map of the human proinsulin biosynthetic interaction network
D. T. Tran, A. Pottekat, S. A. Mir, I. Jang, S. Loguercio, A. R. Campos, R. Lahmy, M. Liu, P. Arvan, W. E. Balch, R. J. Kaufman, P. Itkin-Ansari
This study identifies a conserved proinsulin interactome in human islets, revealing PRDX4's role in proinsulin folding and its inactivation in T2D.
bioRxiv · Jan 15, 2020 · PreprintBiochemistry