W. E. Balch

Covariant Fitness Clusters Reveal Structural Evolution of SARS-CoV-2 Polymerase Across the Human Population

The paper uses Gaussian process regression to analyze SARS-CoV-2 RdRp mutations, identifying fitness clusters that evolve during the pandemic and contribute to viral spread.

A reference map of the human proinsulin biosynthetic interaction network

This study identifies a conserved proinsulin interactome in human islets, revealing PRDX4's role in proinsulin folding and its inactivation in T2D.

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

This study shows valproic acid corrects the folding and trafficking defect of the I1061T-NPC1 mutation, restoring cholesterol homeostasis and suggesting a potential therapeutic approach for Niemann-Pick type C disease.

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone

This study identifies SEW04784, a small molecule that disrupts Aha1-stimulated Hsp90 ATPase activity, showing therapeutic potential in prostate cancer and tauopathies without affecting basal Hsp90 function.

HDAC Inhibitors Rescue Multiple Disease-Causing CFTR Variants

This study shows that HDAC inhibitors correct multiple CFTR variants' function in human bronchial epithelial cells, with synergistic effects when combined with Vx809.