Author

S. A. Mir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

P. Arvan· 3 shared P. Itkin-Ansari· 3 shared R. J. Kaufman· 3 shared A. Pottekat· 2 shared M. Liu· 2 shared S. Loguercio· 2 shared A. Anjum· 1 shared A. R. Campos· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

P. Arvan

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Author profile →

3 papers

Recent·Most cited

Inflammatory cytokines rewire the proinsulin interaction network in human islets

D. Tran, A. Pottekat, K. Lee, M. Raghunathan, S. Loguercio, S. A. Mir, A. W. Paton, J. C. Paton, P. Arvan, R. J. Kaufman, P. Itkin-Ansari

This study identifies how inflammatory cytokines alter the proinsulin interactome in human islets, revealing new interactions and mechanisms involved in diabetes-related proinsulin dysregulation.

bioRxiv · Apr 7, 2022Cell Biology

A reference map of the human proinsulin biosynthetic interaction network

D. T. Tran, A. Pottekat, S. A. Mir, I. Jang, S. Loguercio, A. R. Campos, R. Lahmy, M. Liu, P. Arvan, W. E. Balch, R. J. Kaufman, P. Itkin-Ansari

This study identifies a conserved proinsulin interactome in human islets, revealing PRDX4's role in proinsulin folding and its inactivation in T2D.

bioRxiv · Jan 15, 2020 · PreprintBiochemistry

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

M. Liu, P. Arvan, J. Sun, Y. Xiong, X. Li, L. Haataja, W. Chen, S. A. Mir, R. Madley, D. Larkin, A. Anjum, B. Dhayalan, N. K. Rege, N. D. Wickramasinghe, M. A. Weiss, , D. A. Ostrov

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

bioRxiv · Oct 1, 2019Cell Biology