Author

R. Lea

University of Manchester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. F. Hurlstone· 1 shared A. Monteiro· 1 shared A. P. Badrock· 1 shared C. S. Elcombe· 1 shared C. T. Dee· 1 shared Cerys S ManningiD· 1 shared F. Bottiglione· 1 shared J. E. Allen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

A. F. Hurlstone

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Author profile →

3 papers

Recent·Most cited

Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood

C. S. Elcombe, A. Monteiro, M. Ghasemzadeh-Hasankolaei, V. Padmanabhan, K. Sinclair, R. Lea, N. Evans, M. Bellingham

bioRxiv · Dec 9, 2022Pharmacology & Toxicology

Timing of neurogenesis through sequential accumulation of miR-9 due to additive expression of multiple alleles

Ximena Soto, Joshua Burton, Cerys S Manning, Thomas George Minchington, R. Lea, J. Lee, Jochen Kursawe, Magnus Rattray, Nancy Papalopulu

The paper shows that miR-9 levels increase stepwise during zebrafish neurogenesis through sequential activation of distinct pri-mir-9 loci, which helps overcome adaptation in Her6 dynamics.

bioRxiv · Aug 3, 2020 · PreprintDevelopmental Biology

Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis.

A. F. Hurlstone, F. Bottiglione, C. T. Dee, R. Lea, L. Zeef, A. P. Badrock, M. Wane, L. Bugeon, M. J. Dallman, J. E. Allen

The paper investigates the roles of IL-4-like and IL-10 cytokines in zebrafish gill homeostasis and inflammation, finding that IL-10 is essential while IL-4-like cytokines are not.

bioRxiv · Apr 9, 2020Immunology