Author

R. Lipsh-Sokolik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 3 Approach:machine learning (classical)· 2 Assay:protein structure· 2 Approach:deep learning· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

S. J. Fleishman· 3 shared S. Y. Hoch· 2 shared B. E. Correia· 1 shared C. de Boer· 1 shared C. M. G. Aldaravi· 1 shared C. Yang· 1 shared D. Ivankov· 1 shared D. Liebermann· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

S. J. Fleishman

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 11, 2022

Designed active-site library reveals thousands of functional GFP variants

J. Y. Weinstein, C. M. G. Aldaravi, R. Lipsh-Sokolik…·S. J. Fleishman

The paper designs a library of functional GFP variants using a machine-learning approach, recovering over 16,000 unique sequences with improved thermostability and fluorescence properties.

DOI 10.1101/2022.10.11.511732

protein sequencemachine learning (classical)

𝕏 PostBluesky

BioengineeringbioRxivSep 17, 2022

Combinatorial assembly and design of enzymes

R. Lipsh-Sokolik, O. Khersonsky, S. P. Schroder…·S. J. Fleishman

The paper introduces CADENZ, a machine-learning strategy for designing structurally diverse enzymes, achieving a tenfold improved hit rate and over 10,000 active enzymes.

DOI 10.1126/science.ade9434

protein structuremachine learning (classical)

𝕏 PostBluesky

BiochemistrybioRxivNov 9, 2021

Assessing and enhancing foldability in designed proteins

D. Listov, R. Lipsh-Sokolik, S. Rosset…·S. J. Fleishman

This study develops methods to assess and improve foldability in designed proteins, significantly enhancing catalytic efficiency and stability.

DOI 10.1002/pro.4400

protein structuredeep learning

𝕏 PostBluesky