Combinatorial assembly and design of enzymes
R. Lipsh-Sokolik, O. Khersonsky, S. P. Schroder, C. de Boer, S. Y. Hoch, G. J. Davies, H. S. Overkleeft, S. J. Fleishman
The paper introduces CADENZ, a machine-learning strategy for designing structurally diverse enzymes, achieving a tenfold improved hit rate and over 10,000 active enzymes.
bioRxiv · Sep 17, 2022Bioengineering