Author

R. Peralta

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Immunology· 1

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Poholek· 1 shared A. T. Frisch· 1 shared B. R. Ford· 1 shared G. M. Delgoffe· 1 shared N. E. Scharping· 1 shared N. L. Rittenhouse· 1 shared P. D. A. Vignali· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. C. Poholek

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1 paper

Recent·Most cited

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. R. Ford, N. L. Rittenhouse, N. E. Scharping, P. D. A. Vignali, A. T. Frisch, R. Peralta, G. M. Delgoffe, A. C. Poholek

This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.

bioRxiv · Jul 11, 2021 · PreprintImmunology