Author

A. C. Poholek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

G. M. Delgoffe· 2 shared A. B. Frias· 1 shared A. Burr· 1 shared A. Hettinga· 1 shared A. L. Dent· 1 shared A. N. Fooks· 1 shared A. Overacre-Delgoffe· 1 shared A. Ray· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

G. M. Delgoffe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

A. Burr, J. Ji, K. Ozler, O. Eskiocak, B. Yueh, A. V. Menk, A. S. H. Costa, N. Rittenhouse, C. W. Marshall, P. Chiaranunt, L. Mullinax, A. Overacre-Delgoffe, V. S. Cooper, A. C. Poholek, G. M. Delgoffe, , T. Hand

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

bioRxiv · Aug 18, 2021 · PreprintImmunology

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. R. Ford, N. L. Rittenhouse, N. E. Scharping, P. D. A. Vignali, A. T. Frisch, R. Peralta, G. M. Delgoffe, A. C. Poholek

This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.

bioRxiv · Jul 11, 2021 · PreprintImmunology

Blimp-1 is essential for Th2 cell development and allergic asthma

K. He, A. Hettinga, S. L. Kale, S. Hu, M. M. Xie, A. L. Dent, A. Ray, A. C. Poholek

This study identifies Blimp-1 as a positive regulator of Th2 cell development and allergic asthma through an IL-10-STAT3-Blimp-1 circuit.

bioRxiv · Jan 2, 2020Immunology

Blimp-1 in adipose resident Tregs controls adipocyte beiging and obesity

L. Y. Beppu, X. Qu, G. J. Marrero, A. N. Fooks, A. B. Frias, K. E. Helfrich, I. Sipula, B. Xie, S. C. Watkins, A. C. Poholek, M. J. Jurczak, L. M. D'Cruz

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

bioRxiv · Dec 14, 2019 · PreprintImmunology