Author

P. D. A. Vignali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Poholek· 1 shared A. Lebid· 1 shared A. T. Frisch· 1 shared A. Tam· 1 shared B. R. Ford· 1 shared C. G. Drake· 1 shared C.-T. Huang· 1 shared D. M. Pardoll· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. C. Poholek

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2 papers

Recent·Most cited

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

H. Yu, H. Nishio, J. Barbi, M. Mitchell-Flack, P. D. A. Vignali, Y. Zheng, A. Lebid, K.-Y. Chang, J. Fu, M. Higgins, C.-T. Huang, X. Zhang, Z. Li, L. Blosser, A. Tam, , D. M. Pardoll

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

bioRxiv · Jan 31, 2024Immunology

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. R. Ford, N. L. Rittenhouse, N. E. Scharping, P. D. A. Vignali, A. T. Frisch, R. Peralta, G. M. Delgoffe, A. C. Poholek

This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.

bioRxiv · Jul 11, 2021 · PreprintImmunology