Author

G. M. Delgoffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. C. Poholek· 2 shared A. Bostwick· 1 shared A. Burr· 1 shared A. J. Cipriano· 1 shared A. Overacre-Delgoffe· 1 shared A. S. H. Costa· 1 shared A. T. Frisch· 1 shared A. V. Menk· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. C. Poholek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Thymidine rescues ATR kinase inhibition induced deoxyuridine contamination in genomic DNA, cell death, and Type 1 interferon expression

N. Sugitani, F. P. Vendetti, A. J. Cipriano, P. Pandya, J. J. Deppas, T. N. Moiseeva, S. Schamus-Haynes, Y. Wang, D. Palmer, H. U. Osmanbeyoglu, A. Bostwick, N. W. Snyder, Y.-N. Gong, K. M. Aird, G. M. Delgoffe, , C. J. Bakkenist

This study shows that thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination, cell death, and Type 1 interferon expression in CD8+ T cells.

bioRxiv · Feb 24, 2022 · PreprintCancer Biology

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

A. Burr, J. Ji, K. Ozler, O. Eskiocak, B. Yueh, A. V. Menk, A. S. H. Costa, N. Rittenhouse, C. W. Marshall, P. Chiaranunt, L. Mullinax, A. Overacre-Delgoffe, V. S. Cooper, A. C. Poholek, G. M. Delgoffe, , T. Hand

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

bioRxiv · Aug 18, 2021 · PreprintImmunology

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. R. Ford, N. L. Rittenhouse, N. E. Scharping, P. D. A. Vignali, A. T. Frisch, R. Peralta, G. M. Delgoffe, A. C. Poholek

This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.

bioRxiv · Jul 11, 2021 · PreprintImmunology