Author

R. Purohit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. D. Woods· 1 shared A. E. Ondrus· 1 shared B. Royer-Pokora· 1 shared C. Keller· 1 shared D. M. MacLean· 1 shared D. S. Peng· 1 shared E. Vielmas· 1 shared G. Srivivasa· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. D. Woods

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3 papers

Recent·Most cited

Proline substitutions in the ASIC1 β11-12 linker slow desensitization

R. Purohit, T. Couch, D. M. MacLean

This study shows that proline substitutions in the ASIC1 β11-12 linker significantly slow desensitization, with minimal effects on activation and ion selectivity.

bioRxiv · May 9, 2024Biophysics

Bromodomain 4 inhibition leads to MYCN downregulation in Wilms' tumor cells

A. D. Woods, C. Keller, N. E. Berlow, J. E. Michalek, B. Royer-Pokora, R. Purohit, K. E. Tranbarger Freier, M. Lathara, K. Matlock, G. Srivivasa, R. Veselska

This study shows that BRD4 inhibition reduces MYCN levels and suppresses proliferation in Wilms tumor cells, suggesting AZD5153 as a potential therapeutic agent.

bioRxiv · Jan 4, 2021 · PreprintCancer Biology

Dual roles of the Sterol Recognition Region in Hedgehog protein modification

R. Purohit, D. S. Peng, E. Vielmas, A. E. Ondrus

The paper identifies the role of the sterol recognition region in Hedgehog protein modification through sequence analysis, mutagenesis, and biochemical assays.

bioRxiv · Dec 31, 2019Biochemistry