Author

T. Couch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:chicken / avian· 2 Assay:electrophysiology· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. M. MacLean· 3 shared D. L. Kneisley· 2 shared K. Berger· 1 shared M. L. Rook· 1 shared M. Miaro· 1 shared M. Musgaard· 1 shared P. J. Kammermeier· 1 shared R. Purohit· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

D. M. MacLean

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Author profile →

3 papers

Recent·Most cited

Proline substitutions in the ASIC1 β11-12 linker slow desensitization

R. Purohit, T. Couch, D. M. MacLean

This study shows that proline substitutions in the ASIC1 β11-12 linker significantly slow desensitization, with minimal effects on activation and ion selectivity.

bioRxiv · May 9, 2024Biophysics

Topography and motion of the acid-sensing ion channel intracellular domains

T. Couch, K. Berger, D. L. Kneisley, T. W. McCullock, P. J. Kammermeier, D. M. MacLean

This study uses FRET to map the topography and motion of ASIC1 intracellular domains, revealing structural features and conformational changes under acidification.

bioRxiv · Feb 23, 2021Physiology

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1

M. L. Rook, M. Miaro, T. Couch, D. L. Kneisley, M. Musgaard, D. M. MacLean

This study shows that mutating Gln276 to glycine in ASIC1a does not significantly reduce desensitization, highlighting differences between chicken and human ASICs.

bioRxiv · Dec 19, 2020Biophysics