Cancer BiologybioRxiv
Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism
G. K. L. Chan, S. Maisel, Y. C. Hwang…·J. D. Gordan
This study identifies two PKA-driven oncogenic mechanisms, showing AURKA stabilizes MYC oncoproteins through a PIM2-mediated feedback loop, and suggests CD-532 as a potential therapeutic target.
DOI 10.7554/elife.69521