D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding
C. S. Joshi, A. M. Salazar, C. Wang, M. M. Ligon, R. R. Chappidi, B. E. Fashemi, P. A. Felder, A. Mora, S. L. Grimm, C. Coarfa, I. U. Mysorekar
This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.
bioRxiv · Sep 6, 2022Cell Biology