S. L. Grimm

Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability

This study identifies KDM4A as a centrosome-associated protein whose demethylase activity maintains centrosome integrity and genomic stability.

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct

This study compares infant and adult human intestinal enteroids, finding significant transcriptomic, morphological, and functional differences that highlight their distinct characteristics.

D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding

This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.