Cancer BiologybioRxivPreprint
Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer
S. Nanjo, W. Wu, N. Karachaliou…·T. Bivona
This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.
DOI 10.1101/2020.10.26.356352