Author

R. S. Edgar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. S. O'Neill· 5 shared A. D. Beale· 4 shared A. Zeng· 3 shared A. Stangherlin· 2 shared C. T. Styles· 2 shared D. Bechtold· 2 shared D. C. S. Wong· 2 shared E. A. Hayter· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCell Biology

J. S. O'Neill

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Author profile →

5 papers

Recent·Most cited

A cellular basis for the mammalian nocturnal-diurnal switch

A. D. Beale, M. J. Christmas, N. M. Rzechorzek, A. Mihut, A. Zeng, C. Ellis, N. R. James, N. J. Smyllie, V. Pilorz, R. Richardson, M. F. Bertelsen, S. V. Fazal, Z. Voysey, K. Moreau, J. Pelletier, , J. S. O'Neill

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

bioRxiv · Jun 22, 2023 · PreprintCell Biology

Propylene glycol inactivates respiratory viruses and prevents airborne transmission

C. T. Styles, J. Zhou, K. E. Flight, J. C. Brown, M. Vanden Oever, T. P. Peacock, Z. Wang, R. Millns, J. S. O'Neill, W. S. Barclay, J. S. Tregoning, R. S. Edgar

bioRxiv · Feb 13, 2023Microbiology

Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells

A. D. Beale, E. A. Hayter, P. Crosby, U. K. Valekunja, R. S. Edgar, J. E. Chesham, E. S. Maywood, F. H. Labeed, A. B. Reddy, K. P. Wright, K. S. Lilley, D. Bechtold, M. H. Hastings, J. S. O'Neill

The paper identifies daily haemoglobin oxidation rhythms in red blood cells and links them to core body temperature regulation, independent of circadian mutations in nucleated cells.

bioRxiv · Oct 11, 2021Cell Biology

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

A. Stangherlin, D. C. S. Wong, S. Barbiero, J. L. Watson, A. Zeng, E. Seinkmane, S. P. Chew, A. D. Beale, E. A. Hayter, A. Guna, A. Inglis, E. Bartolami, S. Matile, N. Lequeux, T. Pons, , J. S. O'Neill

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

bioRxiv · May 28, 2020Cell Biology

CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis

D. C. S. Wong, E. Seinkmane, A. Stangherlin, A. Zeng, N. M. Rzechorzek, A. D. Beale, J. Day, M. Reed, S. Y. Peak-Chew, C. T. Styles, R. S. Edgar, M. Putker, J. S. O'Neill

This study compares the circadian proteome and phosphoproteome of wild-type and CRY-deficient fibroblast cells, finding increased circadian-regulated proteins and stress sensitivity in CRY-deficient cells.

bioRxiv · May 16, 2020Cell Biology