A. D. Beale

Potassium rhythms couple the circadian clock to the cell cycle

The paper shows that circadian rhythms in intracellular potassium levels regulate the cell cycle in algae and mammalian cells.

A cellular basis for the mammalian nocturnal-diurnal switch

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

Circadian regulation of macromolecular complex turnover and proteome renewal

This study investigates circadian regulation of protein turnover and proteome renewal, finding that synthesis and degradation rhythms consolidate proteome renewal while minimizing compositional changes.

Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells

The paper identifies daily haemoglobin oxidation rhythms in red blood cells and links them to core body temperature regulation, independent of circadian mutations in nucleated cells.

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis

This study compares the circadian proteome and phosphoproteome of wild-type and CRY-deficient fibroblast cells, finding increased circadian-regulated proteins and stress sensitivity in CRY-deficient cells.