Author

R. Savai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Borowek· 1 shared A. C. Joerger· 1 shared A. Marazioti· 1 shared A. Nist· 1 shared A. Petrera· 1 shared A. S. Lamort· 1 shared C. Malainou· 1 shared D. Brunn· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Borowek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

J. Funk, M. Klimovich, E. Pavlakis, M. Neumann, D. Drangenstein, M. Noeparast, P. Hunold, A. Borowek, D.-I. Balourdas, K. Kochan, N. Merle, I. Bullwinkel, M. Wanzel, S. Elmshauser, A. Nist, , T. Stiewe

This study uses CRISPR mutagenesis to analyze the functional impact of TP53 mutations across 9,225 variants, revealing their effects on tumor cell fitness and metastasis.

bioRxiv · Mar 10, 2023Cancer Biology

Cell-type-specific efferocytosis determines functional plasticity of alveolar macrophages

J. Better, M. Wetstein, M. Estiri, C. Malainou, M. R. Ferrero, M. Langelage, I. Kuznetsova, I. Vazquez-Armendariz, L. Kimmig, S. Mansouri, R. Savai, J. Wilhelm, I. Alexopoulos, N. Sommer, S. Herold, U. Matt

Neutrophil efferocytosis reprograms mitochondrial metabolism to switch alveolar macrophages to a pro-resolution phenotype at the cost of bacterial control.

bioRxiv · Mar 7, 2023Immunology

Tumor-secreted versican co-opts myeloid IKKβ during metastasis

M. Spella, A. S. Lamort, M. Vreka, A. Marazioti, I. Lilis, G. Ntaliarda, G. Skiadas, E. Bouloukou, G. A. Giotopoulou, M. A. Pepe, S. A. Weiss, A. Petrera, S. M. Hauck, I. Koch, M. Lindner, , G. T. Stathopoulos

This study identifies tumor-secreted versican as a driver of myeloid IKKβ activation during metastasis, showing its role in promoting inflammation and metastasis through IL-1β release.

bioRxiv · May 20, 2021 · PreprintCancer Biology