S. Herold

Lineage-tracing of Acta2+ cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblasts to myofibroblast reversible switch

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

Cell-type-specific efferocytosis determines functional plasticity of alveolar macrophages

Neutrophil efferocytosis reprograms mitochondrial metabolism to switch alveolar macrophages to a pro-resolution phenotype at the cost of bacterial control.

FGF10 triggers de novo alveologenesis in a BPD model: impact on the resident mesenchymal niche cells

This study shows that FGF10 administration rescues alveologenesis defects in a BPD mouse model by activating resident mesenchymal niche cells.

Inhibiting coronavirus replication in cultured cells by chemical ER stress

This study shows that thapsigargin inhibits coronavirus replication by modulating ER stress and quality control pathways in cultured cells.

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1

The paper identifies a novel subset of quiescent alveolar type 2 cells in mice that expand after pneumonectomy and are enriched in PD-L1, with similar findings observed in human lungs.

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.