S. M. Hauck

Engineering of human myotubes toward a mature metabolic and contractile phenotype

This paper shows that adding IGF1 to human myoblast cultures improves their contractility and metabolic profile, making them more like mature skeletal muscle.

Human TRMT2A methylates tRNA and contributes to translation fidelity

This study identifies TRMT2A as a tRNA methyltransferase that contributes to translation fidelity by modifying tRNA with m5U at position 54.

Intestinal myofibroblasts regulate intestinal epithelial cell plasticity via YAP/TAZ

This study shows that intestinal myofibroblasts enhance enteroid self-renewal and survival through YAP/TAZ signaling and TGF-β, without involving Wnt.

Proteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity

This study identifies pro-inflammatory signaling and antigen-presenting capacity in stimulated Müller cells, suggesting their active role in chronic retinal inflammation in diabetic retinopathy.

Tumor-secreted versican co-opts myeloid IKKβ during metastasis

This study identifies tumor-secreted versican as a driver of myeloid IKKβ activation during metastasis, showing its role in promoting inflammation and metastasis through IL-1β release.

Inhibition of PLK1-dependent EBNA2 phosphorylation promotes lymphomagenesis in EBV-infected mice.

The paper shows that inhibiting PLK1-dependent EBNA2 phosphorylation enhances EBNA2 activity, promoting lymphoma development in EBV-infected mice.

Chronic hyperglycaemia drives functional impairment of lymphocytes in diabetic INSC94Y transgenic pigs

This study examines immune cell dysfunction in diabetic pigs, finding reduced T cell proliferation and altered metabolic activity linked to chronic hyperglycaemia.

Defining the RBPome of T helper cells to study higher order post-transcriptional gene regulation

The paper identifies the core RNA-binding protein (RBP)ome in human and mouse T helper cells, revealing new regulators of post-transcriptional gene regulation, including Celf1 as a Roquin-1-dependent coregulator of Icos.

Multi-platforms approach for plasma proteomics: complementarity of Olink PEA technology to mass spectrometry-based protein profiling

The paper compares LC-MS/MS and Olink PEA technologies for plasma proteomics, showing that combined use increases proteome coverage and biological insight.

Adaptive mitochondrial regulation of the proteasome

This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.

PAT2 regulates autophagy through vATPase assembly and lysosomal acidification in brown adipocytes

This study shows PAT2 regulates autophagy in brown adipocytes by promoting vATPase assembly and lysosomal acidification in response to amino acid withdrawal.

Neuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina

This study shows that neural retinal-derived caveolin-1 promotes inflammation in the murine retina, as its depletion reduces cytokine production and immune cell infiltration following LPS challenge.

Cell density-dependent ferroptosis in breast cancer is induced by accumulation of polyunsaturated fatty acid-enriched triacylglycerides

This study shows that low cell density in breast cancer cells increases ferroptosis sensitivity by promoting PUFA-enriched TAG accumulation and reducing lipid desaturation.

Interplay of primary bovine lymphocytes and Mycobacterium avium subsp. paratuberculosis shows distinctly different proteome changes and immune pathways in host-pathogen interaction

This study examines how bovine lymphocytes interact with Mycobacterium avium subsp. paratuberculosis, revealing distinct proteome changes and immune pathway activations based on host immune phenotype.

A functional different immune capacity in cattle is associated with higher mastitis incidence

The paper identifies an immune deviant phenotype in cattle associated with increased mastitis risk.

Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity

The paper identifies DOCK8 as an interaction partner of septin 7 in equine lymphocytes and links altered DOCK8 expression and interactions to autoimmune disease mechanisms.