G. T. Stathopoulos

Immune-evasion of KRAS-mutant lung adenocarcinoma mediated by cAMP response element-binding protein

This study identifies CREB-mediated immune evasion in KRAS-mutant lung adenocarcinoma by suppressing neutrophil recruitment through CXCR1 signaling.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

Tumor-secreted versican co-opts myeloid IKKβ during metastasis

This study identifies tumor-secreted versican as a driver of myeloid IKKβ activation during metastasis, showing its role in promoting inflammation and metastasis through IL-1β release.

KRAS signalling in malignant pleural mesothelioma

This study identifies KRAS mutations as a significant driver in human malignant pleural mesothelioma and demonstrates their role in disease initiation and treatment response in mouse models.

An in vivo inflammatory loop potentiates KRAS blockade

The paper shows that KRAS-mutant tumors rely on an inflammatory loop involving C-C-motif chemokine ligand 2/interleukin-1β signaling, making them resistant to KRAS inhibitors in vivo but responsive in certain transplant models.

Organ-restricted vascular delivery of nanoparticles for lung cancer therapy

This study introduces organ-restricted vascular delivery to enhance nanoparticle targeting to lung tumors, showing improved cellular uptake compared to systemic or intratracheal administration.

Dual airway and alveolar contributions to adult lung homeostasis and carcinogenesis

This study identifies airway contributions to alveolar maintenance and lung adenocarcinoma development through mouse models and transcriptomic analysis.