Bile Acid Biosynthesis Avoiding Cholesterol
W. J. Griffiths, J. Abdel-Khalik, P. J. Crick, E. Yutuc, M. Ogundare, B. W. Bigger, A. A. Morris, C. H. Shackleton, P. T. Clayton, T. Iida, R. Sircar, H.-U. Marschall, J. Sjoval, I. Bjorkhem, R. Rohatgi, Y. Wang
The paper identifies a novel bile acid biosynthesis pathway in Smith-Lemli-Opitz syndrome that bypasses cholesterol, starting from 7-dehydrocholesterol, and links intermediates to Hedgehog signaling.
bioRxiv · Aug 5, 2018 · PreprintBiochemistry