Author

R. T. Dame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. N. Volkov· 2 shared F. Ben Bdira· 2 shared L. Qin· 2 shared M. Ubbink· 2 shared A. H. Friggen· 1 shared A. L. Boyle· 1 shared A. M. Erkelens· 1 shared A. M. Lippa· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

A. N. Volkov

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Author profile →

3 papers

Recent·Most cited

Novel anti-repression mechanism of H-NS proteins by a phage "early protein".

F. Ben Bdira, L. Qing, A. N. Volkov, A. M. Lippa, A. M. Erkelens, N. Bowring, A. L. Boyle, M. Ubbink, S. L. Dove, R. T. Dame

This study identifies how phage gp4 modulates H-NS protein MvaT by stabilizing its half-open conformation, relieving gene silencing and affecting P. aeruginosa growth.

bioRxiv · Mar 3, 2021Biochemistry

Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins

L. Qin, F. Ben Bdira, Y. G. J. Sterckx, A. N. Volkov, J. Vreede, G. Giachin, P. van Schaik, M. Ubbink, R. T. Dame

This study identifies the molecular mechanism by which H-NS proteins switch DNA binding states in response to osmotic changes, showing that ionic strength affects electrostatic interactions between domains.

bioRxiv · Sep 5, 2019Biochemistry

The bacterial chromatin protein HupA can remodel DNA and associates with the nucleoid in Clostridium difficile

A. M. Oliveira Paiva, A. H. Friggen, L. Qin, R. Douwes, R. T. Dame, W. K. Smits

This study characterizes HupA, a bacterial chromatin protein in C. difficile, showing it binds DNA, induces conformational changes, and compacts the chromosome.

bioRxiv · Dec 20, 2018Microbiology